The Research

Plato’s three herbal ingredients come from standardized extracts of the best-understood nootropics available.

Here’s the proof.  

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Bacopa Monnieri as Bacognize®, 300mg

Bacopa Monnieri has been in human use for thousands of years as part of the medical traditions of China, India, Russia, and Nepal, among others.

Bacognize® is the best form of Bacopa Monnieri available, having been shown through clinial research to offer a broad array of benefits for cognitive health linked to 5HT serotonin binding activity and antioxidant capacity.

Statistically significant effects of supplementation of Bacopa in general and Bacognize® in specific, at doses of 300-600mg, have been seen in randomized placebo-controlled studies in healthy young adults, healthy older adults, and healthy med students, who could be said to be on their way to a certain kind of adulthood.

Long-term use of Bacopa Monnieri can improve memory. [1,2,3,4,5]

Bacognize® in particular can improve working memory [6, 7], immediate recall [6], short-term memory and cognitive processing speed [8], attention [6, 7], language comprehension [6], focus [7], and mood [8], as well as supporting healthy cognition through aging [9].

Bacognize® is produced by Verdure Sciences in a hands-free botanicals-only facility that is ISO-certified and NSF and GMP registered.


Rhodiola Rosea as Rhodiola5Plus™, 100mg

Rhodiola Rosea is known as a powerful adaptogen with a long tradition of use in Chinese, Russian, and Tibetan folk medicine.

Rhodiola has been studied extensively for its nootropic effects, and RCT studies have shown that supplementation may provide a notable decrease to fatigue [10, 11, 12, 13], increased physical endurance [14] therapeutic effects in stressed subjects [15], and a notable increase to cognition and subjective well-being. [12, 15, 10, 13] A meta-analysis of 11 randomized placebo-controlled trials showed benefits in fatigue reduction during physical activity and increased mental performance under stress. [16]

Plato contains 100mg of Rhodiola standardized to 3% Rosavins and 2% Salidroside, a dosage and potency selected to most closely match the most promising studies available. The Rhodiola in Plato may help support a positive mood [17, 18, 19], may reduce symptoms of stress [20, 21, and may support mental performance and concentration. [21]

Our Rhodiola comes as Rhodiola5Plus™ #2, through Jiaherb’s HerbaLink™ program - a unique chain of custody program geared towards providing the end consumer maximum transparency in botanical ID, sourcing, and traceability.

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Panax Ginseng, Indena® 27-30%, 60mg

Panax Ginseng, from the Greek pan for ‘all’ and axos for ‘cure’, is commonly referred to as the ‘True Ginseng’. Ginseng been used since at least 1st century B.C. in traditional Chinese and Korean medicine as a general tonic.

Plato includes 60mg of concentrated Ginseng extract, which placebo-controlled randomized trials with healthy young subjects have shown may help improve working memory [22], increase calmness [22], support cognitive performance [23, 24], reduce the perception of mental fatigue [23, 24], and improve mental health and social functioning [25].

The Ginseng in Plato comes from Italian producer of supplements and pharmaceuticals Indena® and is produced under cultivation before being standardized to a high potency of not less than 27% Saponins expressed as Ginsenoside Rg1. This Ginseng is non-GMO, vegetarian, non-ionized, and certified Halal.


L-Theanine, 200mg

L-Theanine is a non-dietary, non-essential amino acid found predominantly in tea and some mushrooms. It’s structurally similar to GABA, a neuroamine critical to relaxation, and glutamate, a neurotransmitter critical to learning and memory.

On its own, it increases wakeful relaxation [26], relaxation while resting [27], and brain alpha wave activity [26, 28], while reducing temporary anxiety due to stress [28], and helping to maintain normal blood pressure [28] and heart rate in stressful situations [30].

Taken together with caffeine, L-Theanine has shown to improve speed and accuracy of attention-switching and reduced susceptibility to distraction in memory tasks better than caffeine alone [31, 32]. Adding Theanine to caffeine has been shown to preserve the benefits of caffeine consumption while further improving alertness and reaction time and reducing headache [33], together reducing reaction time and task-switching time while improving attention [31].

Our L-Theanine is not a branded, standardized extract because it’s just a molecule, plain and simple. It doesn’t get much purer than that.

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1. Stough, C., Lloyd, J., Clarke, J., Downey, L. A., Hutchison, C. W., Rodgers, T., & Nathan, P. J. (2001). The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology (Berl), 156(4), 481-484.


2. Stough C., Downey L. A., Lloyd J., et al. (2008) Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial. Phytother Res. 22(12), 1629-34


3. Pase M. P., Kean J., Sarris J., Neale C., Scholey A. B., Stough C. (2012) The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials. J Altern Complement Med. 18(7), 647-52


4. Raghav, S., Singh, H., Dalal, P. K., Srivastava, J. S., & Asthana, O. P. (2006). Randomized controlled trial of standardized Bacopa monniera extract in age-associated memory impairment. Indian J Psychiatry, 48(4), 238-242. doi:10.4103/0019-5545.31555


5. Neale, C., Camfield, D., Reay, J., Stough, C., & Scholey, A. (2013). Cognitive effects of two nutraceuticals Ginseng and Bacopa [...]: a review and comparison of effect sizes. British Journal of Clinical Pharmacology, 75(3), 728-737. doi:10.1111/bcp.12002


6. Kumar et al. (2016) Efficacy of standardized extract of Bacopa monnieri (Bacognize®) on cognitive functions of medical students: A six-week, randomized placebo-controlled trial. Evidence-Based Comp Alter Med. doi: 10.1155/2016/4103423

7. Headapohl et al. Effects of Bacopa monnieri (Bacognize®) on memory and cognitive function in healthy older adults: A double-blind placebo-controlled study. Manuscript.

8. Hingorani L et al. (2012) Sustained cognitive effects and safety of HPLC-standardized Bacopa monnieri (Bacognize®) extract: A randomized, placebo controlled clinical trial. Planta Med. 78-PH22. doi:10.1055/s-0032-1320681


9. Goswami S et al. (2011) Effect of Bacopa monnieri (Bacognize®) on cognitive function in patients. Int J Collab Research Internal Med. 3(4): 285-293. ISSN: 1840-4529

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10. Darbinyan V et al. (2000) Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine. doi:10.1016/S0944-7113(00)80055-0


11. Schutgens FW et al. (2009) The influence of adaptogens on ultraweak biophoton emission: a pilot-experiment. Phytother Res. doi:10.1002/ptr.2753


12. Spasov AA et al. (2000) A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine. doi:10.1016/S0944-7113(00)80078-1


13. Shevtsov VA et al. (2003) A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine. doi:10.1078/094471103321659780



14. De Bock K et al. (2004) Acute Rhodiola rosea intake can improve endurance exercise performance. Int J Sport Nutr Exerc Metab. PMID: 15256690


15. Edwards et al. (2012) Therapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms--results of an open-label study. Phytother Res. doi:10.1002/ptr.3712


16. Hung SK et al. (2011) The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials. Phytomedicine. doi:10.1016/j.phymed.2010.08.014


17.Panossian A et al. (2010) Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine. doi:10.1016/j.phymed.2010.02.002


18. Amsterdam JD et al. (2016) Rhodiola rosea L. as a putative botanical antidepressant. Phytomedicine. doi:10.1016/j.phymed.2016.02.009


19. Cropley M et al. (2015) The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms. Phytother Res. doi:10.1002/ptr.5486


20. Panossian A et al. (2009) Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol. PMID: 19500070


21. Olsson EM et al. (2009) A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Med. doi:10.1055/s-0028-1088346

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22. Reay JL et al. (2010) Panax ginseng (G115) improves aspects of working memory performance and subjective ratings of calmness in healthy young adults. Hum Psychopharmacol. doi:10.1002/hup.1138


23. Reay JL et al. (2006) Effects of Panax ginseng, consumed with and without glucose, on blood glucose levels and cognitive performance during sustained 'mentally demanding' tasks.. J Psychopharmacol. doi:10.1177/0269881106061516


24. Reay JL et al. (2005) Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity. J Psychopharmacol. doi:10.1177/0269881105053286


25. Ellis JM et al. (2002) Effects of Panax ginseng on quality of life. Ann Pharmacother. doi:10.1345/aph.1A2456

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26. Nobre AC et al. (2008) L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr. PMID: 18296328


27. Lu K et al. (2004) The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans. Hum Psychopharmacol. doi:10.1002/hup.611


28. Gomez-Ramirez et al. (2009) The effects of L-theanine on alpha-band oscillatory brain activity during a visuo-spatial attention task. Brain Topogr. doi:10.1007/s10548-008-0068-z


29. Yoto A et al. (2012) Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses. J Physiol Anthropol. doi:10.1186/1880-6805-31-28


30. Kimura K et al. (2007) L-Theanine reduces psychological and physiological stress responses. Biol Physiol. doi:10.1016/j.biopsycho.2006.06.006


31. Owen GN et al. (2008) The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutr Neurosci. doi:10.1179/147683008X301513


32. Giesbrecht T et al. (2010) The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutr Neurosci. doi:10.1179/147683010X12611460764840


33. Haskell CF et al. (2008) The effects of L-theanine, caffeine and their combination on cognition and mood. Biol Psychol. doi:10.1016/j.biopsycho.2007.09.008

































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